Mechanisms and consequences Levodopa + carbidopa and copper interactions are quite complex and not always apparent. The copper-iron and copper-zinc ...
June 18, 2024
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Drug-nutrient interactions
Drug-nutrient interactions are not well-researched.Absence of regulatory requirement
We typically do not know mechanisms of action nor durations of negative impact. Regulatory requirement FOR pharmaceutical impacts on nutritional factors is not required to be included in the drug discovery process. This is surprising given the essentiality of nutrient in health status and the increasing importance being placed on pharmaceuticals to manage ill-health.Likely mechanisms of action
Impairment mechanisms
Primarily in relation to intestinal and renal absorption and/or excretion.Occupation and/or inhibition mechanisms
Transporters can be inhibited which means the nutrients are stuck in either blood or cells until the inhibition resolves. Transporters and carriers are occupied and therefore nutrients cannot be distributed. If blood tests are conducted during inhibition of the nutrient transporter and the substrate is stuck in the –- blood then the results are typically interpreted as excessive dietary intake, and the advice is to reduce intake;
- cells then the results are interpreted as inadequate dietary intake, and a nutrient supplement is typically prescribed.
Example of direct effect
Amiodarone is a P-gp inhibitor (blocks the transporter function) and its substrates include vitamin D. By inhibiting P-gp transporter, amiodarone decreases vitamin D availability during the period of inhibition.Example of indirect effect
Pyridoxine transporter (THTR2) requires an acidic environment (pH 5.5) for absorption. It is likely an acid inhibitor changes absorption site acidity, and therefore THTR2 cannot facilitate pyridoxine absorption. Given the increasing prominence of prescribed medicines in managing health issues, the key drug-nutrient interactions issues we need to know about include which nutrients are negatively impacted, how are they impacted, and what are the best therapeutic management strategies to address that negative impact.Medications & Nutrition Platform
The Medications & Nutrition online platform provides referenced evidence of interactions between prescribed medicines and nutrients. Included, as available, are nutrients impacted, transporters involved, and proposed mechanisms of action. The information is presented in clear dot-point summaries to enable quick access.May 13, 2024
Mechanisms and consequences Levodopa + carbidopa and iron interactions are both complex and extensive. The theories for many of these ...
April 9, 2024
Mechanisms and consequences Levodopa + carbidopa and thiamine encompass a range of interactions that have significant consequences to Parkinson’s Disease ...
March 18, 2024
Levodopa + carbidopa and vitamin C encompass a range of interactions that include both direct and indirect mechanisms of action. ...
March 4, 2024
The levodopa + carbidopa and vitamin D interaction is apparently additive however the evidence is limited. Given Parkinson’s Disease is ...
February 19, 2024
Levodopa + carbidopa and zinc interactions are a surprisingly relatively recent finding. Mechanisms and consequences Levodopa is both a pharmaceutical ...
February 5, 2024
Mechanisms and consequences Is there evidence of a levodopa + carbidopa and manganese interaction? The total metal content and cellular ...
January 29, 2024
The levodopa + carbidopa, magnesium and vitamin C interaction has only recently gained recognition. Mechanisms and consequences Levodopa is commonly ...
December 19, 2023
Mechanisms and consequences Interactions between aspirin and various nutrients have been identified over a number of decades and are either ...
December 13, 2023
An aspirin-folic acid interaction was a recent “incidental finding” from a pooled analysis of some studies looking at brain atrophy ...
December 4, 2023
The aspirin-vitamin C interaction was discovered in the early 1970’s. Mechanisms and consequences The evidence is predominantly based on short ...
March 13, 2023
The mechanisms by which metformin exerts its effects are not fully understood and current concepts are currently being challenged. Mechanisms ...
March 6, 2023
Mechanisms and consequences Aspects of vitamin B6 (pyridoxine) and pharmaconutrition have been written about in previous posts – Metformin & ...
February 27, 2023
Mechanisms and consequences Metformin is a commonly prescribed first line intervention in NIDDM management and its mechanisms of action include ...
February 20, 2023
Metformin was developed and released in the late 1950’s and within a decade was identified as a cause of B12 ...
February 14, 2023
Mechanisms and consequences In many countries, metformin is the first prescribed therapeutic intervention for those diagnosed with Type 2 diabetes. ...
February 6, 2023
A throw-away comment in a relatively recent paper that metformin was associated with diminishing riboflavin(vitamin B2) status prompted this post. ...
January 30, 2023
Membrane transporters are steadily gaining recognition as important factors in the absorption, distribution, metabolism, and excretion of many nutrients, as ...
January 23, 2023
Mechanisms and consequences Metformin is the fourth most commonly prescribed medicine in the world therefore it’s negative impacts on nutritional ...
November 21, 2022
Warfarin is an anticoagulant for which there is a well-known coagulation interaction with vitamin K however its interactions with other ...
