Mechanisms and consequencesVitamin K encompasses several compounds that have similar structures and physiological functions –vitamin K3 - the basic, simplest ...
November 14, 2022
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- Category: Drug-Nutrient interactions
Drug-nutrient interactions is not well-researched. We typically do not know mechanisms of action nor durations of negative impact. Further, there is no regulatory requirement FOR pharmaceutical impacts on nutritional factors to be included in the drug discovery process. This is surprising given the essentiality of nutrient in health status and the increasing importance being placed on pharmaceuticals to manage ill-health.
If inadequate intake is excluded, then the 3 key likely mechanisms that pharmaceuticals can have on nutrient availability include –
If blood tests are conducted during inhibition of the nutrient transporter and the substrate is stuck in the –
Example of direct effect. Amiodarone is a P-gp inhibitor (blocks the transporter function) and its substrates include vitamin D. By inhibiting P-gp transporter, amiodarone decreases vitamin D availability during the period of inhibition.
Example of indirect effect. Pyridoxine transporter (THTR2) requires an acidic environment (pH 5.5) for absorption. It is likely an acid inhibitor changes absorption site acidity, and therefore THTR2 cannot facilitate pyridoxine absorption.
Given the increasing prominence of prescribed medicines in managing health issues, the key drug-nutrient interactions issues we need to know about include which nutrients are negatively impacted, how are they impacted, and what are the best therapeutic management strategies to address that negative impact.
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