Mechanisms and consequences Vitamin K encompasses several compounds that have similar structures and physiological functions – vitamin K3 - the ...
November 14, 2022
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Drug-nutrient interactions
Drug-nutrient interactions are not well-researched.Absence of regulatory requirement
We typically do not know mechanisms of action nor durations of negative impact. Regulatory requirement FOR pharmaceutical impacts on nutritional factors is not required to be included in the drug discovery process. This is surprising given the essentiality of nutrient in health status and the increasing importance being placed on pharmaceuticals to manage ill-health.Likely mechanisms of action
Impairment mechanisms
Primarily in relation to intestinal and renal absorption and/or excretion.Occupation and/or inhibition mechanisms
Transporters can be inhibited which means the nutrients are stuck in either blood or cells until the inhibition resolves. Transporters and carriers are occupied and therefore nutrients cannot be distributed. If blood tests are conducted during inhibition of the nutrient transporter and the substrate is stuck in the –- blood then the results are typically interpreted as excessive dietary intake, and the advice is to reduce intake;
- cells then the results are interpreted as inadequate dietary intake, and a nutrient supplement is typically prescribed.
Example of direct effect
Amiodarone is a P-gp inhibitor (blocks the transporter function) and its substrates include vitamin D. By inhibiting P-gp transporter, amiodarone decreases vitamin D availability during the period of inhibition.Example of indirect effect
Pyridoxine transporter (THTR2) requires an acidic environment (pH 5.5) for absorption. It is likely an acid inhibitor changes absorption site acidity, and therefore THTR2 cannot facilitate pyridoxine absorption. Given the increasing prominence of prescribed medicines in managing health issues, the key drug-nutrient interactions issues we need to know about include which nutrients are negatively impacted, how are they impacted, and what are the best therapeutic management strategies to address that negative impact.Medications & Nutrition Platform
The Medications & Nutrition online platform provides referenced evidence of interactions between prescribed medicines and nutrients. Included, as available, are nutrients impacted, transporters involved, and proposed mechanisms of action. The information is presented in clear dot-point summaries to enable quick access.April 12, 2022
Mechanisms and consequences Whilst researching a related topic for a soon-to-be-published MedNut Mail email, I came across this diagram and ...
February 15, 2022
Mechanisms and consequences … hSVCT1 (Sodium Vitamin C Transporter 1) expression and function were significantly decreased in intestinal epithelial cells ...
January 18, 2022
Mechanisms and consequences Calcium carbonate is a commonly prescribed therapeutic intervention and is listed on the Pharmaceutical Benefits Scheme (PBS). ...
November 16, 2021
Mechanisms and outcomes Because chlorpromazine (a phenothiazine), imipramine (a tricyclic acid) and amitriptyline (a tricyclic acid) have very similar structures ...
November 9, 2021
Methotrexate is both an antagonist and an analogue of folic acid ie it is a nutrient-derivative drug. Mechanisms and outcomes ...
