Mechanisms and consequencesSteady state concentration is the period during which the therapeutic levels remain constant. It is achieved when a ...

Mechanisms and consequencesI now understand why duration of therapeutic effect of the non-insulin diabetes drugs is not an integral part ...

Mechanisms and consequencesInsulin resistance is defined as a lack of cellular response to insulin – likely due to closed, damaged ...

Mechanisms and consequencesInsulin is a highly effective anabolic hormone that is primarily produced in the pancreas, and small amounts are ...

Mechanisms and consequencesSupported by policies, practices and programs, harm minimisation is essentially a philosophy, in a range of sectors, to ...

Mechanisms and consequencesDenosumab is prescribed for the treatment of bone loss in adults at high risk of bone fractures. It ...

Mechanisms and consequencesBone health is so important and so overlooked and is usually only considered once there is a problem.Bone ...

Guest case studyA reader sent in this list of prescribed medications and did not provide any other information.Drug-food interactionsAllopurinolHigh intake ...

Mechanisms and consequencesNeuroinflammation occurs when the brain’s innate immune system is challenged by factors such as injury, infection, toxin exposure, ...

Mechanisms and consequencesCosts of inaction is a term typically associated with business decisions. What are the costs if you choose ...

Mechanisms and consequencesPantothenate is important in many basic physiological functions, and especially as a precursor for Coenzyme A also known ...

Mechanisms and consequencesAstrocytes are overlooked essential intermediaries in neurological physiology. Astrocytes operate on a network system whereby they service hundreds, ...

Mechanisms and consequencesElevated blood levels of nutrients are currently neither looked for nor considered to contribute clinically to disease processes ...

Mechanisms and consequencesPyridoxine (Vitamin B6) is important in many body functions and is seemingly now becoming “sexy” to some in ...

Time-saving templatesTemplates are useful for ensuring essential information is passed on without any aspect being overlooked as they can be ...

Mechanisms and consequencesPantothenate is a nutrient that is very out-of-sight and out-of-mind – is there, or should there be, a ...

Mechanisms and consequencesThe combination of identification of physiological transporters and their potential for accessing currently inaccessible-for-pharmaceuticals parts of the body ...

Mechanisms and consequencesPhysiological transporters (aka “drug transporters”) are seemingly a one-way gate for substances to pass from one carrier to ...

Mechanisms and consequencesA recent seminal study (DOI 10.1074/jbc.RA120.013610) found that ThTr1/2 (Thiamine Transporters 1/2) can transport both thiamine and pyridoxine ...