Permeability-glycoprotein is known as P-glycoprotein or P-gp or multidrug resistance protein (MDR1/2). Mechanisms and consequences P-gp has a large and ...
June 12, 2023
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Distribution system
The body’s distribution system is an intricate framework of local transporters, hubs, and systemic carriers. This framework enables the collection and carriage of substances throughout the body and to their point of excretion.Distribution system in the body
Transporters.
The shuttle buses aka the local delivery service. Approximately 9 transporters are required to be tested for and identified in the drug discovery process and Product Information documents. Not all known transporters are required to be identified in the drug discovery process and Product Information documents eg glucose transporters. The vast majority are unknown and euphemistically referred to as “passive diffusion”.Carriers.
The systemic carriers that typically move load from a departure point to an arrivals point, for local distribution. The main carrier is albumin, followed by alpha-1 acid glycoprotein, and then several niche carriers.Nutritional consequences
Our poor understanding of the body’s distribution systems means potential drug-distribution-nutrition interactions remain hidden.May 29, 2023
The Sodium Vitamin C Transporters (SVCTs) regulate vitamin C homeostasis (system stability) such that excessive intakes result in reduced intestinal ...
May 22, 2023
Mechanisms and consequences MATE1/2 (Multi drug and toxin exclusion transporters MATE1 and MATE2) are major efflux transporters involved in the ...
May 15, 2023
BCRP (Breast Cancer Resistance Protein) seems to be an initial defence against environmental insults such as phototoxic skin lesions, and ...
May 8, 2023
Mechanisms and consequences The thiamine transporters Thiamine Transporter 1 (THTR1) and Thiamine Transporter 2 (THTR2) transfer thiamine and pyridoxine, and ...
May 1, 2023
SMVT (Sodium Multivitamin Transporter) facilitates the uptake of biotin, pantothenic acid, lipoic acid, and iodine from the gut and across ...
April 10, 2023
OCTs regulate the transfer of many essential organic cations across biological membranes and therefore have an essential role in many ...
April 3, 2023
Membrane transporters enable substances to cross impermeable cell membranes. Whilst they primarily transfer endogenous substances such as nutrients, they can ...
June 21, 2022
Elevated blood levels of nutrients are currently neither looked for nor considered to contribute clinically to disease processes and so ...
May 10, 2022
Mechanisms and consequences Physiological transporters (aka “drug transporters”) are seemingly a one-way gate for substances to pass from one carrier ...
November 1, 2021
Mechanisms and consequences What do physiological transporters aka drug transporters and bus services have in common? Networks, hubs, defined load ...
August 10, 2021
Mechanisms and consequences Membrane transporters Membrane transporters are euphemistically called “drug transporters” however their primary role is to move physiological ...
