Comprehensive and reliable information on drug-nutrient and drug-food interactions

Imagine the moment - you effortlessly accessed the evidence you needed on a drug-nutrient interaction - and instantly added it to your clinical notes. That’s what we deliver.

1. What Do I Get?

Easy, Evidence-Based Access. Quickly identify drugs that impact nutritional status, all sourced from reliable, credible references.

M&N is your go-to, comprehensive resource for drugs and their nutritional effects—presented from a nutritional perspective, so you can act with confidence.

2. How Does It Work for Me?

Time Saver:

   - Instantly find and use evidence-based information

   - Easily integrate into your workflow

Knowledge:

   - Learn from topical updates and real-world case studies

Resources:

   - Credible, reliable, updated regularly

3. How Long Will It Take?

Time to benefit is simply the time you invest in reviewing and updating your clinical report templates and standardizing your drug and diagnosis-based templates. Once set up, you only need to update as new evidence emerges.

4. What Do I Need to Do?

 Review and update your clinical report templates.

 Standardize your drug and diagnosis templates.

 Modify as new evidence becomes available.

5. What If I Don’t Act?

If you’re compared to colleagues who integrate PharmacoNutrition into their clinical advice, you risk losing the confidence of your clients in your competence and management strategies.

6. Who Is This Not For?

M&N is not for those who do not believe that addressing drug-induced mal-nutrition will enhance therapeutic interventions.

Empower your practice with M&N - the trusted resource for PharmacoNutrition and start integrating evidence-based drug-nutrient insights into your care today! Sign up now!!

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Subsequent year renewals attract a discount as thank you for your continuing support.

Sample page

Brand name:  Pastiche (mix)

Generic name: Sample

Function/Action: XXXX

Nutrients affected

Adverse reactions

Biochemical factors

Na142

B126, 84

B1270

folate1, 2

Nausea8, 41, 98

Vomiting8, 41, 98

Constipation8, 41, 98

Diarrhoea8, 41, 98

­­­Inc Weight8, 41, 98

­Dec Appetite8, 41, 98

Altered taste8, 41

Dry mouth1, 2

Dysphagia8, 41, 98

hypoalbuminaemia8, 41

anaemia8, 41, 98

hypoglycaemia1

hyperglycaemia2

hypokalaemia8, 41

hypocalcaemia8, 41, 98

hypophosphataemia8, 41, 98

hyperthyroidism41

hypercholesterolaemia41

Nutritional care

Pharmacokinetics

  • Binding of drug to plasma proteins ~ 96%8, 41.
  • Associated with cytochrome P450 pathway, isozyme 3A48, 41, 98.
  • Can be administered before meals or with meals, however choice must remain consistent8, 41.
  • Associated with altered thyroid function41, 369, and diabetes41.

Drug Food Interactions

  • Grapefruit and grapefruit juice contra-indicated8, 41.

Drug Nutrient Interactions

  • Concurrent administration with diuretic has a synergistic effect for hyponatraemia142.
  • Regular measurement of serum sodium levels recommended142.

Membrane transporters

  • Drug is an OCT1inhibitor (blocks transporter function)14, 57, 370. OCT1 functions as a major thiamine transporter11, 12, 13, 15, 16, 17, 18 that can also transport choline11, 13, 19, 20 and tyramine11, 12, from the portal vein into liver hepatocytes11, 13, 15, 17, 19, 21, 22.
  • Drug is a BCRP substrate (can be carried by the transporter)8. BCRP substrates include riboflavin30, 31, folic acid31, 32, 33, vitamin K331, pantothenate34, and inhibitors include vitamin D235, and cranberry metabolites36.
  • Drug is a P-gp substrate (can be carried by the transporter)8. P-gp substrates include pyridoxine34, nicotinamide34, pantothenate34, cobalamin37, vitamin D38 and P-gp inhibitors includes vitamin A39.

Non Oral Feeding

  • Tablets not to be crushed, chewed or broken8, 41.
  • If jejunostomy then poor absorption of iron due to bypassing stomach (solubilizes iron) and duodenum (primary site of iron absorption)392, 393, 394; jejunum is unable to upregulate iron absorption sufficiently to compensate for duodenal bypass392.

Impaired Swallow

  • Tablets not to be crushed, chewed or broken8, 41.

Note - superscripted numbers are reference numbers.

Together, we are challenging concepts

and perceptions,

and consequently creating change -

and it feels risky and scary!

Anonymous

Medications & Nutrition

comprehensive and reliable information, easy-to-use

So many people have asked us for advice on how to apply the information in a clinically-useful manner, so we developed 3 resources based on our trials and experience for you to download and adapt to your requirements.

Explanatory tips on the layout of the database

Explains data layout

To view image and/or download - click on image

Suggestions for applying the information

Outlines formats for integrating pharmaconutrition into clinical assessments

Click image to view and download

Expandable tables to present summary information

Useful tables guide cover

Click image to either open or download

How to integrate medications and nutrition into your clinical practice flowchart

The best sequence for applying the information
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