Drug-induced hypoalbuminaemia (low albumin) is a multifaceted issue that impacts physiological function both directly and indirectly. Albumin is the primary ...
July 15, 2025
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Distribution system
The body’s distribution system is an intricate framework of local transporters, hubs, and systemic carriers. This framework enables the collection and carriage of substances throughout the body and to their point of excretion.Distribution system in the body
Transporters.
The shuttle buses aka the local delivery service. Approximately 9 transporters are required to be tested for and identified in the drug discovery process and Product Information documents. Not all known transporters are required to be identified in the drug discovery process and Product Information documents eg glucose transporters. The vast majority are unknown and euphemistically referred to as “passive diffusion”.Carriers.
The systemic carriers that typically move load from a departure point to an arrivals point, for local distribution. The main carrier is albumin, followed by alpha-1 acid glycoprotein, and then several niche carriers.Nutritional consequences
Our poor understanding of the body’s distribution systems means potential drug-distribution-nutrition interactions remain hidden.July 1, 2025
Albumin’s haem site is important in regulating free haem levels within our blood. Mechanisms and consequences Haem sources Free ...
June 17, 2025
The zinc switch is an excellent example of an albumin-based drug-nutrient interaction mechanism. Mechanisms and consequences The Zinc ...
June 3, 2025
Albumin and the fatty acids (FAs) interactions have an important physiological relationship. Mechanisms and consequences Albumin is a key carrier ...
May 20, 2025
Albumin and thyroxine, either separately or together, are important contributors to most of our physiological functions. Mechanisms and consequences Albumin ...
May 6, 2025
Albumin and minerals in combination encompass a broad range of physiological functions – and yet the research is surprisingly limited. ...
April 15, 2025
Albumin and vitamins are essential for body function as albumin is either a primary or secondary carrier for most vitamins. ...
April 1, 2025
Albumin is a glycoprotein that is the primary, blood-specific carrier in the body’s distribution network. Mechanisms and consequences Albumin is ...
March 17, 2025
Albumin aka Human Serum Albumin (HSA) is the main protein in the blood. Mechanisms and consequences Albumin is ...
March 3, 2025
Mechanisms and consequences The body’s distribution system comprises a framework of local transporters, hubs, and systemic carriers. We see ...
November 25, 2024
Chromium is very important in enhancing the signalling cascade that stimulates insulin-dependent glucose transporters such as GLUT4 to translocate. Mechanisms ...
November 11, 2024
AMPK mechanisms and consequences AMPK (adenosine monophosphate-activated protein kinase) is an energy sensor in the cells. It rebalances adenosine ...
October 21, 2024
PKC mechanisms and consequences PKC (Protein Kinase C) is a second pathway that stimulates insulin-dependent glucose transporters to translocate. Outlined ...
September 30, 2024
Glucose transporters and insulin function is rarely considered whilst “insulin and blood sugars” is integral to many care discussions. Mechanisms ...
September 10, 2024
Glucose transporters SGLTs (sodium-dependent glucose transporters) are one of the three identified families of glucose transporters in humans. Mechanisms and ...
August 27, 2024
The glucose transporters SWEETs is a relatively recent discovery about which not much is known. Mechanisms and consequences The SWEETs ...
August 13, 2024
Mechanisms and consequences Glucose transporters (GLUTs) and sodium–glucose linked transporters (SGLTs) are the regulatory pathways essential for glucose homeostasis. Glucose ...
August 1, 2023
Multidrug resistance proteins (MRPs) are efflux transporters and as such are responsible for the movement of a wide variety of ...
July 10, 2023
OATs (Organic Anion Transporters) are primarily influx transporters albeit some are bidirectional. Mechanisms and consequences OATs can transport a wide variety ...
June 26, 2023
OATPs (Organic Anion Transporting Proteins) are influx transporters ie transport substrates from blood into organs and cells. Mechanisms and consequences ...
