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  • Category: PharmacoNutrition

The interface between prescribed medicines and nutritional factors is so overlooked that it is commonly referred to as drug-nutrient interactions. We decided PharmacoNutrition is a suitable name as it encompasses the broad scope of the field. Pharmaconutrition interactions are overlooked because -

  • research papers are scattered across a plethora of journals and subjects;
  • the studies are mostly small;
  • there is an assumption, without evidence, that food intake will cover the drug-induced nutrient losses;
  • there is also an assumption by the pharmaceutical sector that food is benign – this assumption is steadily being eroded,
  • the training for doctors and pharmacists training does not include a significant nutrition component. This is surprising given 80+% of western ill-health has an underlying negative nutrition component.
The ultimate question is “Who will conduct the research?”:
  • pharmaceutical industry. The regulatory processes do not require negative nutritional impacts of pharmaceutical products to be included in the drug discovery process;
  • governmental research bodies. The number of similarly worthwhile research projects competing for funding is steadily increasing whilst the funding sources generally are not;
  • philanthropic bodies. Philanthropic bodies either support a specific area of research or dispense smaller grants to a larger number of applicants. Sadly, there aren't any philanthropic bodies with a particular interest in this area of expertise.
PharmacoNutrition comprises 2 components -
  • accessing the information, and
  • presenting the findings in a clinically meaningful format.
The online platform Medications & Nutrition provides a comprehensive range of clinically-useful, referenced, research evidence that is presented in a dot point format to improve accessibility to the latest research for busy clinicians. Examples of integration formats are included in the Case study component of our MedNut Mail series.

July 15, 2025

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Drug-induced hypoalbuminaemia

Drug-induced hypoalbuminaemia (low albumin) is a multifaceted issue that impacts physiological function both directly and indirectly. Albumin is the primary ...

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July 1, 2025

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Albumin’s haem site

Albumin’s haem site is important in regulating free haem levels within our blood.​Mechanisms and consequencesHaem sourcesFree haem sources include newly-produced ...

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June 17, 2025

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Albumin and the Zinc Switch

Mechanisms and consequencesThe Zinc SwitchThe zinc switch is an excellent example of an albumin-based drug-nutrient interaction mechanism.Essentially the zinc switch ...

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June 3, 2025

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Albumin and the fatty acids interactions

Mechanisms and consequencesAlbumin and the fatty acids (FAs) interactions have an important physiological relationship. Albumin is a key carrier for ...

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May 20, 2025

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Albumin and thyroxine

Mechanisms and consequencesAlbumin and thyroxine, either separately or together, are important contributors to most of our physiological functions. Albumin carries ...

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May 6, 2025

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Albumin and minerals in combination

Mechanisms and consequencesAlbumin and minerals in combination encompass a broad range of physiological. Albumin’s multiple metal binding sites enables it ...

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April 15, 2025

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Albumin and vitamins

Mechanisms and consequencesAlbumin and vitamins are essential for body function as albumin is either a primary or secondary carrier for ...

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April 1, 2025

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Albumin and glucose

Mechanisms and consequencesAlbumin is a glycoprotein that is the primary, blood-specific carrier in the body’s distribution network. It is not ...

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March 17, 2025

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About albumin

Mechanisms and consequencesAlbumin aka Human Serum Albumin (HSA) is the main protein in the blood. It is part of a ...

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March 3, 2025

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Distribution system

Mechanisms and consequencesThe body’s distribution system comprises a framework of local transporters, hubs, and systemic carriers. We see examples of ...

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February 4, 2025

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Drug administration for dysphagia

Mechanisms and consequencesDrug administration for dysphagia is a fraught issue. Many pharmaceutical manufacturers recommend their products not be crushed, chewed, ...

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December 9, 2024

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Drug-induced hyperglycaemia

​Mechanisms and consequences Drug-induced hyperglycaemia is not a formally recognised diagnosis but is a very common side effect of many ...

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November 25, 2024

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Glucose transporters and chromium

Mechanisms and consequences Chromium is very important in enhancing the signalling cascade that stimulates insulin-dependent glucose transporters such as GLUT4 to ...

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November 11, 2024

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Glucose transporters and AMPK

AMPK mechanisms and consequencesAMPK (adenosine monophosphate-activated protein kinase) is an energy sensor in the cells. It rebalances adenosine triphosphate (ATP) ...

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October 21, 2024

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Glucose transporters and PKC

PKC mechanisms and consequencesPKC (Protein Kinase C) is a second pathway that stimulates insulin-dependent glucose transporters to translocate.Outlined below are ...

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September 30, 2024

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Glucose transporters and insulin function

Mechanisms and consequencesGlucose transporters and insulin function is rarely considered whilst “insulin and blood sugars” is integral to many care ...

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September 10, 2024

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Glucose transporters SGLTs

Mechanisms and consequencesGlucose transporters SGLTs (sodium-dependent glucose transporters) are one of the three identified families of glucose transporters in humans.Being ...

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August 27, 2024

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Glucose transporters SWEETs

Mechanisms and consequencesThe glucose transporters SWEETs is a relatively recent discovery about which not much is known. The SWEETs are ...

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August 13, 2024

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Glucose transporters (GLUTs)

Mechanisms and consequencesGlucose transporters (GLUTs) and sodium–glucose linked transporters (SGLTs) are the regulatory pathways essential for glucose homeostasis. Glucose is ...

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June 4, 2024

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The interdependence of copper-iron interactions

Mechanisms and consequencesThe interdependence of copper-iron interactions, and their importance in health management, remains overlooked and under-researched. Deficiencies or excesses ...

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