Mechanisms and consequencesAlbumin aka Human Serum Albumin (HSA) is the main protein in the blood. It is part of a ...

Mechanisms and consequencesThe body’s distribution system comprises a framework of local transporters, hubs, and systemic carriers. We see examples of ...

Mechanisms and consequencesDrug administration for dysphagia is a fraught issue. Many pharmaceutical manufacturers recommend their products not be crushed, chewed, ...

Mechanisms and consequences Chromium is very important in enhancing the signalling cascade that stimulates insulin-dependent glucose transporters such as GLUT4 to ...

AMPK mechanisms and consequencesAMPK (adenosine monophosphate-activated protein kinase) is an energy sensor in the cells. It rebalances adenosine triphosphate (ATP) ...

PKC mechanisms and consequencesPKC (Protein Kinase C) is a second pathway that stimulates insulin-dependent glucose transporters to translocate.Outlined below are ...

Mechanisms and consequencesGlucose transporters SGLTs (sodium-dependent glucose transporters) are one of the three identified families of glucose transporters in humans.Being ...

Mechanisms and consequencesThe glucose transporters SWEETs is a relatively recent discovery about which not much is known. The SWEETs are ...

Mechanisms and consequencesGlucose transporters (GLUTs) and sodium–glucose linked transporters (SGLTs) are the regulatory pathways essential for glucose homeostasis. Glucose is ...

Mechanisms and consequencesThe interdependence of copper-iron interactions, and their importance in health management, remains overlooked and under-researched. Deficiencies or excesses ...

Mechanisms and consequencesDrug-induced tipping points and health management strategies are an unlikely combination and rarely considered. A common definition (https://global-tipping-points.org/what-is-a-tipping-point/) ...

Mechanisms and consequencesOsmolality seems to be a rarely-considered contributor to a range of primarily gastro-intestinal side effects. It is probably ...

Mechanisms and consequencesNot to be crushed, chewed, broken or dissolved and its many variations are commonly included in most Product ...

Mechanisms and consequencesExcipients are the ingredients that comprise about 90% of a medicine - they are added to optimise some ...

Mechanisms and consequences“Not clinically relevant”, “inhibition unlikely at therapeutic interventions”, “clinical inhibition deemed minimal”, and similar other phrases typically refer ...

Mechanisms and consequencesThe side effects of many prescribed medicines include altered glycaemic status which is associated with physical harm to ...

Mechanisms and consequencesMultidrug resistance proteins (MRPs) are efflux transporters and as such are responsible for the movement of a wide ...

Guest case studyGuest case study - hypercalcaemia is based on a question from a concerned clinician.Oral calcium intake - no ...